The purpose of this PhD studentship is to investigate the propensity of protein-based biopharmaceuticals to aggregate. Aggregation is one of the major pathways of degradation for proteins during storage and processing and is, therefore, a key indicator for the robustness of a formulation and process.
This studenship will be funded for a period of three years and the aim will be to support and increase the understanding of product robustness to operational conditions. The study will use stress models during processes such as Formulation, Filtration, Transfer and Filling. The work will be supported by an external collaborator who will model the aggregation mechanism and process. The external collaborator (an expert firm) will act as consultants and collaborate with the successful candidate to develop mechanistic models to estimate the propensity of proteins to aggregate.
As a leading global biotechnology company we have one mission every day: to lastingly improve the lives of people living with rare diseases. Crucial to our mission are our employees – our biggest asset – who enjoy a range of benefits and career opportunities, such as trainee and training programs, job rotations, apprenticeships, work-life balance (certified family friendly), company kindergarten, wellness center, cafeteria, etc.
We offer outstanding opportunities to motivated people regardless of your gender, age, skin color, ethnicity, sexual orientation or physical handicaps. Diversity is part of our success.
The minimum salary for this position is € 2.000 gross per month (for 32 hours); increased payment is possible. We are looking forward to your application.